BDBM50359981 CHEMBL1927770
SMILES: FC(F)(F)c1cc(CC(=O)N[C@@H](Cc2ccccc2)C(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2ccccc32)cc(c1)C(F)(F)F
InChI Key: InChIKey=WUCNRALGPZNATI-SANMLTNESA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50359981 (CHEMBL1927770) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 171 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UMR 6216 Curated by ChEMBL | Assay Description Inhibition of Met-mediated scattering in HGF-stimulated human MDCK cells pre-incubated overnight prior to HGF stimulation for 24 hrs measured after 2... | Eur J Med Chem 47: 239-54 (2012) Article DOI: 10.1016/j.ejmech.2011.10.051 BindingDB Entry DOI: 10.7270/Q2XK8FZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50359981 (CHEMBL1927770) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 321 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UMR 6216 Curated by ChEMBL | Assay Description Inhibition of Met-mediated tumorigenesis in HGF-stimulated human HepG2 cells assessed as impairment in anchorage-independent growth by soft agar grow... | Eur J Med Chem 47: 239-54 (2012) Article DOI: 10.1016/j.ejmech.2011.10.051 BindingDB Entry DOI: 10.7270/Q2XK8FZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Canis familiaris) | BDBM50359981 (CHEMBL1927770) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Inhibition of Met-triggered cell scattering in HGF-stimulated MDCK cells preincubated for overnight before HGF challenge measured after 24 to 48 hrs | Bioorg Med Chem Lett 22: 4693-6 (2012) Article DOI: 10.1016/j.bmcl.2012.05.078 BindingDB Entry DOI: 10.7270/Q2PV6MF0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50359981 (CHEMBL1927770) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UMR 6216 Curated by ChEMBL | Assay Description Inhibition of TPR-fused MET-mediated mouse BA/F3 cell proliferation after 48 hrs by cell titre blue based spectrophotometry | Eur J Med Chem 47: 239-54 (2012) Article DOI: 10.1016/j.ejmech.2011.10.051 BindingDB Entry DOI: 10.7270/Q2XK8FZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50359981 (CHEMBL1927770) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 811 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UMR 6216 Curated by ChEMBL | Assay Description Inhibition of Met-mediated tumorigenesis in HGF-stimulated human GTL16 cells assessed as impairment in anchorage-independent growth by soft agar grow... | Eur J Med Chem 47: 239-54 (2012) Article DOI: 10.1016/j.ejmech.2011.10.051 BindingDB Entry DOI: 10.7270/Q2XK8FZT | |||||||||||
More data for this Ligand-Target Pair |