Found 4 hits for monomerid = 50360177 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50360177
(CHEMBL1929555)Show SMILES Nc1nc(Nc2ccc(Cl)cc2)c2cc(Cc3cccc4ccccc34)[nH]c2n1 Show InChI InChI=1S/C23H18ClN5/c24-16-8-10-17(11-9-16)26-21-20-13-18(27-22(20)29-23(25)28-21)12-15-6-3-5-14-4-1-2-7-19(14)15/h1-11,13H,12H2,(H4,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of EGFR tyrosine kinase activity in EGF-stimulated human A431 cells after 60 mins by ELISA |
Bioorg Med Chem 20: 910-4 (2012)
Article DOI: 10.1016/j.bmc.2011.11.058 BindingDB Entry DOI: 10.7270/Q27W6CMN |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50360177
(CHEMBL1929555)Show SMILES Nc1nc(Nc2ccc(Cl)cc2)c2cc(Cc3cccc4ccccc34)[nH]c2n1 Show InChI InChI=1S/C23H18ClN5/c24-16-8-10-17(11-9-16)26-21-20-13-18(27-22(20)29-23(25)28-21)12-15-6-3-5-14-4-1-2-7-19(14)15/h1-11,13H,12H2,(H4,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISA |
Bioorg Med Chem 20: 910-4 (2012)
Article DOI: 10.1016/j.bmc.2011.11.058 BindingDB Entry DOI: 10.7270/Q27W6CMN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50360177
(CHEMBL1929555)Show SMILES Nc1nc(Nc2ccc(Cl)cc2)c2cc(Cc3cccc4ccccc34)[nH]c2n1 Show InChI InChI=1S/C23H18ClN5/c24-16-8-10-17(11-9-16)26-21-20-13-18(27-22(20)29-23(25)28-21)12-15-6-3-5-14-4-1-2-7-19(14)15/h1-11,13H,12H2,(H4,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 tyrosine kinase activity in VEGF-stimulated human A498 cells after 60 mins by ELISA |
Bioorg Med Chem 20: 910-4 (2012)
Article DOI: 10.1016/j.bmc.2011.11.058 BindingDB Entry DOI: 10.7270/Q27W6CMN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50360177
(CHEMBL1929555)Show SMILES Nc1nc(Nc2ccc(Cl)cc2)c2cc(Cc3cccc4ccccc34)[nH]c2n1 Show InChI InChI=1S/C23H18ClN5/c24-16-8-10-17(11-9-16)26-21-20-13-18(27-22(20)29-23(25)28-21)12-15-6-3-5-14-4-1-2-7-19(14)15/h1-11,13H,12H2,(H4,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISA |
Bioorg Med Chem 20: 910-4 (2012)
Article DOI: 10.1016/j.bmc.2011.11.058 BindingDB Entry DOI: 10.7270/Q27W6CMN |
More data for this Ligand-Target Pair | |