BDBM50361190 CHEMBL1934321

SMILES: CN1CCC(COc2ccc3c(Nc4ccc(CC(=O)Nc5cccc(F)c5)cc4)ncnc3c2)CC1

InChI Key: InChIKey=HIARAULRLOIBRW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50361190   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50361190 (CHEMBL1934321) Show SMILES CN1CCC(COc2ccc3c(Nc4ccc(CC(=O)Nc5cccc(F)c5)cc4)ncnc3c2)CC1 Show InChI InChI=1S/C29H30FN5O2/c1-35-13-11-21(12-14-35)18-37-25-9-10-26-27(17-25)31-19-32-29(26)34-23-7-5-20(6-8-23)15-28(36)33-24-4-2-3-22(30)16-24/h2-10,16-17,19,21H,11-15,18H2,1H3,(H,33,36)(H,31,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged VEGFR2 intracellular domain using biotin-aminohexyl-EEEEYFELVAKKKK-NH2 as substrate after 30 mins by HTRF assay				Bioorg Med Chem Lett 22: 110-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.061 BindingDB Entry DOI: 10.7270/Q2H132FD
					More data for this Ligand-Target Pair