BDBM50361217 CHEMBL1934346

SMILES: NC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4ncccn4)n3n2)cc1

InChI Key: InChIKey=HENGJELRUQAYJK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50361217   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50361217 (CHEMBL1934346) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4ncccn4)n3n2)cc1 Show InChI InChI=1S/C23H24N8O/c24-21(32)15-30-12-8-17(9-13-30)16-2-4-18(5-3-16)28-23-27-14-19-6-7-20(31(19)29-23)22-25-10-1-11-26-22/h1-7,10-11,14,17H,8-9,12-13,15H2,(H2,24,32)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant FAK expressed in baculovirus expression system after 30 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361217 (CHEMBL1934346) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4ncccn4)n3n2)cc1 Show InChI InChI=1S/C23H24N8O/c24-21(32)15-30-12-8-17(9-13-30)16-2-4-18(5-3-16)28-23-27-14-19-6-7-20(31(19)29-23)22-25-10-1-11-26-22/h1-7,10-11,14,17H,8-9,12-13,15H2,(H2,24,32)(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair