BDBM50361847 CHEMBL1938798::US9150577, 190

SMILES: O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1

InChI Key: InChIKey=MVRDTJDXYOJXNF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50361847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribosomal protein S6 kinase alpha 2 (Homo sapiens (Human))	BDBM50361847 (CHEMBL1938798 | US9150577, 190) Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1 Show InChI InChI=1S/C22H18N4O2/c27-21(25-17-10-14-4-1-2-5-18(14)24-13-17)16-7-6-15-11-20-22(28)23-8-3-9-26(20)19(15)12-16/h1-2,4-7,10-13H,3,8-9H2,(H,23,28)(H,25,27)	Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...				US Patent US9150577 (2015) BindingDB Entry DOI: 10.7270/Q2GB22V6
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50361847 (CHEMBL1938798 | US9150577, 190) Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1 Show InChI InChI=1S/C22H18N4O2/c27-21(25-17-10-14-4-1-2-5-18(14)24-13-17)16-7-6-15-11-20-22(28)23-8-3-9-26(20)19(15)12-16/h1-2,4-7,10-13H,3,8-9H2,(H,23,28)(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of RSK2 phosphorylation by luminescence assay				Bioorg Med Chem Lett 22: 733-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.030 BindingDB Entry DOI: 10.7270/Q2XW4K7N
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50361847 (CHEMBL1938798 | US9150577, 190) Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1 Show InChI InChI=1S/C22H18N4O2/c27-21(25-17-10-14-4-1-2-5-18(14)24-13-17)16-7-6-15-11-20-22(28)23-8-3-9-26(20)19(15)12-16/h1-2,4-7,10-13H,3,8-9H2,(H,23,28)(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter gene				Bioorg Med Chem Lett 22: 733-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.030 BindingDB Entry DOI: 10.7270/Q2XW4K7N
					More data for this Ligand-Target Pair