BDBM50361848 CHEMBL1938799::US9150577, 19

SMILES: CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCCn5c4c3)cnc12

InChI Key: InChIKey=CHFKZEPYDHGBQK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50361848   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribosomal protein S6 kinase alpha 2 (Homo sapiens (Human))	BDBM50361848 (CHEMBL1938799 | US9150577, 19) Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCCn5c4c3)cnc12 Show InChI InChI=1S/C22H22N6O2/c1-13(2)28-20-16(11-25-28)8-17(12-24-20)26-21(29)15-5-4-14-9-19-22(30)23-6-3-7-27(19)18(14)10-15/h4-5,8-13H,3,6-7H2,1-2H3,(H,23,30)(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...				US Patent US9150577 (2015) BindingDB Entry DOI: 10.7270/Q2GB22V6
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50361848 (CHEMBL1938799 | US9150577, 19) Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCCn5c4c3)cnc12 Show InChI InChI=1S/C22H22N6O2/c1-13(2)28-20-16(11-25-28)8-17(12-24-20)26-21(29)15-5-4-14-9-19-22(30)23-6-3-7-27(19)18(14)10-15/h4-5,8-13H,3,6-7H2,1-2H3,(H,23,30)(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of RSK2 phosphorylation by luminescence assay				Bioorg Med Chem Lett 22: 733-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.030 BindingDB Entry DOI: 10.7270/Q2XW4K7N
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50361848 (CHEMBL1938799 | US9150577, 19) Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCCn5c4c3)cnc12 Show InChI InChI=1S/C22H22N6O2/c1-13(2)28-20-16(11-25-28)8-17(12-24-20)26-21(29)15-5-4-14-9-19-22(30)23-6-3-7-27(19)18(14)10-15/h4-5,8-13H,3,6-7H2,1-2H3,(H,23,30)(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter gene				Bioorg Med Chem Lett 22: 733-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.030 BindingDB Entry DOI: 10.7270/Q2XW4K7N
					More data for this Ligand-Target Pair