null

SMILES: O=C(Nc1nc2ccccc2o1)c1ccc2cc3C(=O)NCCCn3c2c1

InChI Key: InChIKey=XEMRFXZAJHTFCF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50361850   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribosomal protein S6 kinase alpha-2 (Homo sapiens (Human))	BDBM50361850 (CHEMBL1938802 | US9150577, 112) Show SMILES O=C(Nc1nc2ccccc2o1)c1ccc2cc3C(=O)NCCCn3c2c1 Show InChI InChI=1S/C20H16N4O3/c25-18(23-20-22-14-4-1-2-5-17(14)27-20)13-7-6-12-10-16-19(26)21-8-3-9-24(16)15(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,26)(H,22,23,25)	Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	370	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...				US Patent US9150577 (2015) BindingDB Entry DOI: 10.7270/Q2GB22V6
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50361850 (CHEMBL1938802 | US9150577, 112) Show SMILES O=C(Nc1nc2ccccc2o1)c1ccc2cc3C(=O)NCCCn3c2c1 Show InChI InChI=1S/C20H16N4O3/c25-18(23-20-22-14-4-1-2-5-17(14)27-20)13-7-6-12-10-16-19(26)21-8-3-9-24(16)15(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,26)(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	367	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of RSK2 phosphorylation by luminescence assay				Bioorg Med Chem Lett 22: 733-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.030 BindingDB Entry DOI: 10.7270/Q2XW4K7N
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50361850 (CHEMBL1938802 | US9150577, 112) Show SMILES O=C(Nc1nc2ccccc2o1)c1ccc2cc3C(=O)NCCCn3c2c1 Show InChI InChI=1S/C20H16N4O3/c25-18(23-20-22-14-4-1-2-5-17(14)27-20)13-7-6-12-10-16-19(26)21-8-3-9-24(16)15(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,26)(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter gene				Bioorg Med Chem Lett 22: 733-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.030 BindingDB Entry DOI: 10.7270/Q2XW4K7N
					More data for this Ligand-Target Pair