BDBM50362062 CHEMBL1940106

SMILES: COc1cc2ncnc(Nc3cnn(CC(=O)Nc4ccc(cn4)N(C)C)c3)c2cc1OC

InChI Key: InChIKey=OTLBXDXENSMYGU-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50362062   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50362062 (CHEMBL1940106) Show SMILES COc1cc2ncnc(Nc3cnn(CC(=O)Nc4ccc(cn4)N(C)C)c3)c2cc1OC Show InChI InChI=1S/C22H24N8O3/c1-29(2)15-5-6-20(23-10-15)28-21(31)12-30-11-14(9-26-30)27-22-16-7-18(32-3)19(33-4)8-17(16)24-13-25-22/h5-11,13H,12H2,1-4H3,(H,23,28,31)(H,24,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	453	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of VEGFR3 phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50362062 (CHEMBL1940106) Show SMILES COc1cc2ncnc(Nc3cnn(CC(=O)Nc4ccc(cn4)N(C)C)c3)c2cc1OC Show InChI InChI=1S/C22H24N8O3/c1-29(2)15-5-6-20(23-10-15)28-21(31)12-30-11-14(9-26-30)27-22-16-7-18(32-3)19(33-4)8-17(16)24-13-25-22/h5-11,13H,12H2,1-4H3,(H,23,28,31)(H,24,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of FLT3 phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50362062 (CHEMBL1940106) Show SMILES COc1cc2ncnc(Nc3cnn(CC(=O)Nc4ccc(cn4)N(C)C)c3)c2cc1OC Show InChI InChI=1S/C22H24N8O3/c1-29(2)15-5-6-20(23-10-15)28-21(31)12-30-11-14(9-26-30)27-22-16-7-18(32-3)19(33-4)8-17(16)24-13-25-22/h5-11,13H,12H2,1-4H3,(H,23,28,31)(H,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CSF1R phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50362062 (CHEMBL1940106) Show SMILES COc1cc2ncnc(Nc3cnn(CC(=O)Nc4ccc(cn4)N(C)C)c3)c2cc1OC Show InChI InChI=1S/C22H24N8O3/c1-29(2)15-5-6-20(23-10-15)28-21(31)12-30-11-14(9-26-30)27-22-16-7-18(32-3)19(33-4)8-17(16)24-13-25-22/h5-11,13H,12H2,1-4H3,(H,23,28,31)(H,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>200	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair