BDBM50362070 CHEMBL1940114

SMILES: COc1cccc(NC(=O)Cn2cc(Oc3ccnc4cc(OC)c(cc34)C#N)cn2)c1

InChI Key: InChIKey=RDWQPGCGRCTSIN-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50362070   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50362070 (CHEMBL1940114) Show SMILES COc1cccc(NC(=O)Cn2cc(Oc3ccnc4cc(OC)c(cc34)C#N)cn2)c1 Show InChI InChI=1S/C23H19N5O4/c1-30-17-5-3-4-16(9-17)27-23(29)14-28-13-18(12-26-28)32-21-6-7-25-20-10-22(31-2)15(11-24)8-19(20)21/h3-10,12-13H,14H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	282	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of VEGFR3 phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50362070 (CHEMBL1940114) Show SMILES COc1cccc(NC(=O)Cn2cc(Oc3ccnc4cc(OC)c(cc34)C#N)cn2)c1 Show InChI InChI=1S/C23H19N5O4/c1-30-17-5-3-4-16(9-17)27-23(29)14-28-13-18(12-26-28)32-21-6-7-25-20-10-22(31-2)15(11-24)8-19(20)21/h3-10,12-13H,14H2,1-2H3,(H,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of FLT3 phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50362070 (CHEMBL1940114) Show SMILES COc1cccc(NC(=O)Cn2cc(Oc3ccnc4cc(OC)c(cc34)C#N)cn2)c1 Show InChI InChI=1S/C23H19N5O4/c1-30-17-5-3-4-16(9-17)27-23(29)14-28-13-18(12-26-28)32-21-6-7-25-20-10-22(31-2)15(11-24)8-19(20)21/h3-10,12-13H,14H2,1-2H3,(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CSF1R phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50362070 (CHEMBL1940114) Show SMILES COc1cccc(NC(=O)Cn2cc(Oc3ccnc4cc(OC)c(cc34)C#N)cn2)c1 Show InChI InChI=1S/C23H19N5O4/c1-30-17-5-3-4-16(9-17)27-23(29)14-28-13-18(12-26-28)32-21-6-7-25-20-10-22(31-2)15(11-24)8-19(20)21/h3-10,12-13H,14H2,1-2H3,(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair