BDBM50362090 CHEMBL1940275

SMILES: COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC

InChI Key: InChIKey=FQGHYVHLTQUXGX-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50362090   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50362090 (CHEMBL1940275) Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	485	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of VEGFR3 phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50362090 (CHEMBL1940275) Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50362090 (CHEMBL1940275) Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of FLT3 phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50362090 (CHEMBL1940275) Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	485	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 22: 3050-5 (2012) Article DOI: 10.1016/j.bmcl.2012.03.074 BindingDB Entry DOI: 10.7270/Q298881Z
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50362090 (CHEMBL1940275) Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CSF-1R				Bioorg Med Chem Lett 22: 3050-5 (2012) Article DOI: 10.1016/j.bmcl.2012.03.074 BindingDB Entry DOI: 10.7270/Q298881Z
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50362090 (CHEMBL1940275) Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta				Bioorg Med Chem Lett 22: 3050-5 (2012) Article DOI: 10.1016/j.bmcl.2012.03.074 BindingDB Entry DOI: 10.7270/Q298881Z
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50362090 (CHEMBL1940275) Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of Flt3				Bioorg Med Chem Lett 22: 3050-5 (2012) Article DOI: 10.1016/j.bmcl.2012.03.074 BindingDB Entry DOI: 10.7270/Q298881Z
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50362090 (CHEMBL1940275) Show SMILES COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(c4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H26N6O3/c1-15(2)30-13-18(12-27-30)28-23(31)9-16-5-7-17(8-6-16)29-24-19-10-21(32-3)22(33-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,31)(H,25,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CSF1R phosphorylation by cell based assay				Bioorg Med Chem Lett 22: 262-6 (2011) Article DOI: 10.1016/j.bmcl.2011.11.019 BindingDB Entry DOI: 10.7270/Q24F1R6H
					More data for this Ligand-Target Pair