BDBM50362205 CHEMBL1938846
SMILES: CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1nc2ccc(F)c(F)c2[nH]1
InChI Key: InChIKey=KAZMUPAZDCLXBU-DTORHVGOSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50362205 (CHEMBL1938846) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding... | Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50362205 (CHEMBL1938846) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 134 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ... | Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD | |||||||||||
More data for this Ligand-Target Pair |