BDBM50362215 CHEMBL1938976

SMILES: CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2ccc(F)c(F)c2[nH]1

InChI Key: InChIKey=XXLURZVRCADLAD-DTORHVGOSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50362215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50362215 (CHEMBL1938976) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2ccc(F)c(F)c2[nH]1 |r| Show InChI InChI=1S/C15H17F2N5/c1-21-4-8-6-22(7-9(8)5-21)14(18)15-19-11-3-2-10(16)12(17)13(11)20-15/h2-3,8-9,18H,4-7H2,1H3,(H,19,20)/t8-,9+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...				Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50362215 (CHEMBL1938976) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2ccc(F)c(F)c2[nH]1 |r| Show InChI InChI=1S/C15H17F2N5/c1-21-4-8-6-22(7-9(8)5-21)14(18)15-19-11-3-2-10(16)12(17)13(11)20-15/h2-3,8-9,18H,4-7H2,1H3,(H,19,20)/t8-,9+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	49	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...				Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD
					More data for this Ligand-Target Pair