null

SMILES: COc1cc(C)c(c(C)c1)-c1nn2c(C)cc(C(C)C)c2c(=O)n1C

InChI Key: InChIKey=JRNCKWTUYHHHMD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50362278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50362278 (CHEMBL1939602) Show SMILES COc1cc(C)c(c(C)c1)-c1nn2c(C)cc(C(C)C)c2c(=O)n1C |(30.32,-42.59,;30.32,-41.05,;28.99,-40.28,;27.66,-41.05,;26.33,-40.28,;24.99,-41.05,;26.33,-38.75,;27.65,-37.98,;27.65,-36.44,;28.98,-38.74,;25,-37.98,;23.66,-38.75,;22.33,-37.98,;20.86,-38.45,;20.38,-39.92,;19.96,-37.21,;20.86,-35.96,;20.39,-34.5,;21.42,-33.35,;18.88,-34.17,;22.33,-36.44,;23.66,-35.66,;23.65,-34.12,;24.99,-36.43,;26.33,-35.65,)| Show InChI InChI=1S/C20H25N3O2/c1-11(2)16-10-14(5)23-18(16)20(24)22(6)19(21-23)17-12(3)8-15(25-7)9-13(17)4/h8-11H,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay				Bioorg Med Chem 20: 1122-38 (2012) Article DOI: 10.1016/j.bmc.2011.11.015 BindingDB Entry DOI: 10.7270/Q2B27VQT
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50362278 (CHEMBL1939602) Show SMILES COc1cc(C)c(c(C)c1)-c1nn2c(C)cc(C(C)C)c2c(=O)n1C |(30.32,-42.59,;30.32,-41.05,;28.99,-40.28,;27.66,-41.05,;26.33,-40.28,;24.99,-41.05,;26.33,-38.75,;27.65,-37.98,;27.65,-36.44,;28.98,-38.74,;25,-37.98,;23.66,-38.75,;22.33,-37.98,;20.86,-38.45,;20.38,-39.92,;19.96,-37.21,;20.86,-35.96,;20.39,-34.5,;21.42,-33.35,;18.88,-34.17,;22.33,-36.44,;23.66,-35.66,;23.65,-34.12,;24.99,-36.43,;26.33,-35.65,)| Show InChI InChI=1S/C20H25N3O2/c1-11(2)16-10-14(5)23-18(16)20(24)22(6)19(21-23)17-12(3)8-15(25-7)9-13(17)4/h8-11H,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13.1	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter				Bioorg Med Chem 20: 1122-38 (2012) Article DOI: 10.1016/j.bmc.2011.11.015 BindingDB Entry DOI: 10.7270/Q2B27VQT
					More data for this Ligand-Target Pair