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BDBM50362323 CHEMBL1939945

SMILES: CN(C)[C@H]1CCN(C1)C(=O)C[C@H]1N(C=CNC1=O)S(=O)(=O)c1cccc(Cl)c1Cl

InChI Key: InChIKey=ICXUHFPOXPFVJB-GXTWGEPZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50362323   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362323
PNG
(CHEMBL1939945)
Show SMILES CN(C)[C@H]1CCN(C1)C(=O)C[C@H]1N(C=CNC1=O)S(=O)(=O)c1cccc(Cl)c1Cl |r,c:14|
Show InChI InChI=1S/C18H22Cl2N4O4S/c1-22(2)12-6-8-23(11-12)16(25)10-14-18(26)21-7-9-24(14)29(27,28)15-5-3-4-13(19)17(15)20/h3-5,7,9,12,14H,6,8,10-11H2,1-2H3,(H,21,26)/t12-,14+/m0/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20.3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair