BindingDB PrimarySearch_ki

Search and Browse
- Target
- Compound
- Special tools
- Citation
- Special Data Sets
- Other Databases
  - PDB 85% 100% Seq ID
  - UniProtKB/Swiss-Prot
  - UniProtKB/TrEMBL
  - PubMed
Download
- All Compounds & Data
- Target Names &
  - Ki IC50 Kd EC50
  - ΔG° ΔH° -TΔS°
Enter Data

null

SMILES: CC(C)(C)c1ccc(CSc2nc(N)cc(=O)[nH]2)cc1

InChI Key: InChIKey=ASEDNWCJVUADNB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50362567
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50362567 (CHEMBL1313991) Show SMILES CC(C)(C)c1ccc(CSc2nc(N)cc(=O)[nH]2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Displacement of dofetilide from human ERG				Bioorg Med Chem Lett 22: 1055-60 (2012) Article DOI: 10.1016/j.bmcl.2011.11.111 BindingDB Entry DOI: 10.7270/Q2CV4J7X
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50362567 (CHEMBL1313991) Show SMILES CC(C)(C)c1ccc(CSc2nc(N)cc(=O)[nH]2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay				Bioorg Med Chem Lett 22: 1055-60 (2012) Article DOI: 10.1016/j.bmcl.2011.11.111 BindingDB Entry DOI: 10.7270/Q2CV4J7X
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50362567 (CHEMBL1313991) Show SMILES CC(C)(C)c1ccc(CSc2nc(N)cc(=O)[nH]2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at partially inactivated human sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assay				Bioorg Med Chem Lett 22: 1055-60 (2012) Article DOI: 10.1016/j.bmcl.2011.11.111 BindingDB Entry DOI: 10.7270/Q2CV4J7X
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50362567 (CHEMBL1313991) Show SMILES CC(C)(C)c1ccc(CSc2nc(N)cc(=O)[nH]2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay				Bioorg Med Chem Lett 22: 1055-60 (2012) Article DOI: 10.1016/j.bmcl.2011.11.111 BindingDB Entry DOI: 10.7270/Q2CV4J7X
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50362567 (CHEMBL1313991) Show SMILES CC(C)(C)c1ccc(CSc2nc(N)cc(=O)[nH]2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at non-inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay				Bioorg Med Chem Lett 22: 1055-60 (2012) Article DOI: 10.1016/j.bmcl.2011.11.111 BindingDB Entry DOI: 10.7270/Q2CV4J7X
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair