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SMILES: Cc1n[nH]c2nc3c(C)cc(Cl)cc3c(N3CCNCC3)c12

InChI Key: InChIKey=NRLSVTKPEVVAHT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50362737   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50362737
PNG
(CHEMBL1939785)
Show SMILES Cc1n[nH]c2nc3c(C)cc(Cl)cc3c(N3CCNCC3)c12
Show InChI InChI=1S/C16H18ClN5/c1-9-7-11(17)8-12-14(9)19-16-13(10(2)20-21-16)15(12)22-5-3-18-4-6-22/h7-8,18H,3-6H2,1-2H3,(H,19,20,21)
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Article
PubMed
 35n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assay

Bioorg Med Chem Lett 22: 1019-22 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.127
BindingDB Entry DOI: 10.7270/Q2BV7H3J
More data for this
Ligand-Target Pair