Found 6 hits for monomerid = 50362978 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50362978
(CHEMBL1945497)Show SMILES CN(C)CCCc1ccc(OC(F)(F)F)c(Nc2ncc3CC(=S)Nc4cc(Cl)ccc4-c3n2)c1 Show InChI InChI=1S/C24H23ClF3N5OS/c1-33(2)9-3-4-14-5-8-20(34-24(26,27)28)19(10-14)31-23-29-13-15-11-21(35)30-18-12-16(25)6-7-17(18)22(15)32-23/h5-8,10,12-13H,3-4,9,11H2,1-2H3,(H,30,35)(H,29,31,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of KIT |
J Med Chem 55: 197-208 (2012)
Article DOI: 10.1021/jm2011172 BindingDB Entry DOI: 10.7270/Q21C1XBR |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50362978
(CHEMBL1945497)Show SMILES CN(C)CCCc1ccc(OC(F)(F)F)c(Nc2ncc3CC(=S)Nc4cc(Cl)ccc4-c3n2)c1 Show InChI InChI=1S/C24H23ClF3N5OS/c1-33(2)9-3-4-14-5-8-20(34-24(26,27)28)19(10-14)31-23-29-13-15-11-21(35)30-18-12-16(25)6-7-17(18)22(15)32-23/h5-8,10,12-13H,3-4,9,11H2,1-2H3,(H,30,35)(H,29,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of FGFR1 |
J Med Chem 55: 197-208 (2012)
Article DOI: 10.1021/jm2011172 BindingDB Entry DOI: 10.7270/Q21C1XBR |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK3
(Homo sapiens (Human)) | BDBM50362978
(CHEMBL1945497)Show SMILES CN(C)CCCc1ccc(OC(F)(F)F)c(Nc2ncc3CC(=S)Nc4cc(Cl)ccc4-c3n2)c1 Show InChI InChI=1S/C24H23ClF3N5OS/c1-33(2)9-3-4-14-5-8-20(34-24(26,27)28)19(10-14)31-23-29-13-15-11-21(35)30-18-12-16(25)6-7-17(18)22(15)32-23/h5-8,10,12-13H,3-4,9,11H2,1-2H3,(H,30,35)(H,29,31,32) | PDB
NCI pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PLK3 |
J Med Chem 55: 197-208 (2012)
Article DOI: 10.1021/jm2011172 BindingDB Entry DOI: 10.7270/Q21C1XBR |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50362978
(CHEMBL1945497)Show SMILES CN(C)CCCc1ccc(OC(F)(F)F)c(Nc2ncc3CC(=S)Nc4cc(Cl)ccc4-c3n2)c1 Show InChI InChI=1S/C24H23ClF3N5OS/c1-33(2)9-3-4-14-5-8-20(34-24(26,27)28)19(10-14)31-23-29-13-15-11-21(35)30-18-12-16(25)6-7-17(18)22(15)32-23/h5-8,10,12-13H,3-4,9,11H2,1-2H3,(H,30,35)(H,29,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDGFRb |
J Med Chem 55: 197-208 (2012)
Article DOI: 10.1021/jm2011172 BindingDB Entry DOI: 10.7270/Q21C1XBR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50362978
(CHEMBL1945497)Show SMILES CN(C)CCCc1ccc(OC(F)(F)F)c(Nc2ncc3CC(=S)Nc4cc(Cl)ccc4-c3n2)c1 Show InChI InChI=1S/C24H23ClF3N5OS/c1-33(2)9-3-4-14-5-8-20(34-24(26,27)28)19(10-14)31-23-29-13-15-11-21(35)30-18-12-16(25)6-7-17(18)22(15)32-23/h5-8,10,12-13H,3-4,9,11H2,1-2H3,(H,30,35)(H,29,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
J Med Chem 55: 197-208 (2012)
Article DOI: 10.1021/jm2011172 BindingDB Entry DOI: 10.7270/Q21C1XBR |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50362978
(CHEMBL1945497)Show SMILES CN(C)CCCc1ccc(OC(F)(F)F)c(Nc2ncc3CC(=S)Nc4cc(Cl)ccc4-c3n2)c1 Show InChI InChI=1S/C24H23ClF3N5OS/c1-33(2)9-3-4-14-5-8-20(34-24(26,27)28)19(10-14)31-23-29-13-15-11-21(35)30-18-12-16(25)6-7-17(18)22(15)32-23/h5-8,10,12-13H,3-4,9,11H2,1-2H3,(H,30,35)(H,29,31,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of FLT3 |
J Med Chem 55: 197-208 (2012)
Article DOI: 10.1021/jm2011172 BindingDB Entry DOI: 10.7270/Q21C1XBR |
More data for this Ligand-Target Pair | |