BDBM50363891 CHEMBL1946119

SMILES: Cn1c2ccn(CC(=O)Nc3nc(cs3)-c3ccc(cc3)C(F)(F)F)c2c(=O)n(C)c1=O

InChI Key: InChIKey=SHLKDPMPLSENMB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50363891   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50363891 (CHEMBL1946119) Show SMILES Cn1c2ccn(CC(=O)Nc3nc(cs3)-c3ccc(cc3)C(F)(F)F)c2c(=O)n(C)c1=O Show InChI InChI=1S/C20H16F3N5O3S/c1-26-14-7-8-28(16(14)17(30)27(2)19(26)31)9-15(29)25-18-24-13(10-32-18)11-3-5-12(6-4-11)20(21,22)23/h3-8,10H,9H2,1-2H3,(H,24,25,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Antagonist activity at human TRPA1 expressed in human IMR90 cells assessed as inhibition of acrolein-induced calcium influx after 40 mins by fluoresc...				Bioorg Med Chem 20: 1690-8 (2012) Article DOI: 10.1016/j.bmc.2012.01.020 BindingDB Entry DOI: 10.7270/Q2NV9JQK
					More data for this Ligand-Target Pair