BDBM50363956 CHEMBL1952025
SMILES: Nc1ncnc2CCN(C(=O)c12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
InChI Key: InChIKey=DVHSQIPHRVBFFO-HDJSIYSDSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human)) | BDBM50363956 (CHEMBL1952025) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of full length human microsomal DGAT-1 expressed in baculovirus infected insect Sf9 cells using [14C]decanoylCoA as substrate after 1.5 hr... | ACS Med Chem Lett 2: 407-412 (2011) Article DOI: 10.1021/ml200051p BindingDB Entry DOI: 10.7270/Q2MW2HM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human)) | BDBM50363956 (CHEMBL1952025) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta counting | ACS Med Chem Lett 2: 407-412 (2011) Article DOI: 10.1021/ml200051p BindingDB Entry DOI: 10.7270/Q2MW2HM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM50363956 (CHEMBL1952025) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human DGAT-2 | ACS Med Chem Lett 2: 407-412 (2011) Article DOI: 10.1021/ml200051p BindingDB Entry DOI: 10.7270/Q2MW2HM6 | |||||||||||
More data for this Ligand-Target Pair |