null

SMILES: CNc1ncnc2sc3c(ccn(-c4ccc(C)cc4)c3=O)c12

InChI Key: InChIKey=ZUOKDHCWCLGJBQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50364716   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (RAT)	BDBM50364716 (CHEMBL1951888) Show SMILES CNc1ncnc2sc3c(ccn(-c4ccc(C)cc4)c3=O)c12 Show InChI InChI=1S/C17H14N4OS/c1-10-3-5-11(6-4-10)21-8-7-12-13-15(18-2)19-9-20-16(13)23-14(12)17(21)22/h3-9H,1-2H3,(H,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	97	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at rat metabotropic glutamate receptor 1				Bioorg Med Chem Lett 22: 1575-8 (2012) Article DOI: 10.1016/j.bmcl.2011.12.131 BindingDB Entry DOI: 10.7270/Q2F19063
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50364716 (CHEMBL1951888) Show SMILES CNc1ncnc2sc3c(ccn(-c4ccc(C)cc4)c3=O)c12 Show InChI InChI=1S/C17H14N4OS/c1-10-3-5-11(6-4-10)21-8-7-12-13-15(18-2)19-9-20-16(13)23-14(12)17(21)22/h3-9H,1-2H3,(H,18,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human metabotropic glutamate receptor 1				Bioorg Med Chem Lett 22: 1575-8 (2012) Article DOI: 10.1016/j.bmcl.2011.12.131 BindingDB Entry DOI: 10.7270/Q2F19063
					More data for this Ligand-Target Pair