null

SMILES: COc1ccc2c(CC(O)=O)c([nH]c2c1)C(=O)c1cc(C)ccn1

InChI Key: InChIKey=BVLDTQOJHAZUMB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50365158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50365158 (CHEMBL1950010) Show SMILES COc1ccc2c(CC(O)=O)c([nH]c2c1)C(=O)c1cc(C)ccn1 Show InChI InChI=1S/C18H16N2O4/c1-10-5-6-19-15(7-10)18(23)17-13(9-16(21)22)12-4-3-11(24-2)8-14(12)20-17/h3-8,20H,9H2,1-2H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of COX-1-mediated TXB2 production in human platelets preincubated for 20 mins prior A23187 stimulation measured after 15 mins by RIA				Eur J Med Chem 50: 179-95 (2012) Article DOI: 10.1016/j.ejmech.2012.01.053 BindingDB Entry DOI: 10.7270/Q2B27VR8
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50365158 (CHEMBL1950010) Show SMILES COc1ccc2c(CC(O)=O)c([nH]c2c1)C(=O)c1cc(C)ccn1 Show InChI InChI=1S/C18H16N2O4/c1-10-5-6-19-15(7-10)18(23)17-13(9-16(21)22)12-4-3-11(24-2)8-14(12)20-17/h3-8,20H,9H2,1-2H3,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of COX-2-mediated PGE2 production in LPS-induced human whole blood after 24 hrs by RIA				Eur J Med Chem 50: 179-95 (2012) Article DOI: 10.1016/j.ejmech.2012.01.053 BindingDB Entry DOI: 10.7270/Q2B27VR8
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50365158 (CHEMBL1950010) Show SMILES COc1ccc2c(CC(O)=O)c([nH]c2c1)C(=O)c1cc(C)ccn1 Show InChI InChI=1S/C18H16N2O4/c1-10-5-6-19-15(7-10)18(23)17-13(9-16(21)22)12-4-3-11(24-2)8-14(12)20-17/h3-8,20H,9H2,1-2H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of COX-1-mediated TXB2 production in human whole blood after 15 mins post A23187 stimulation by RIA				Eur J Med Chem 50: 179-95 (2012) Article DOI: 10.1016/j.ejmech.2012.01.053 BindingDB Entry DOI: 10.7270/Q2B27VR8
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50365158 (CHEMBL1950010) Show SMILES COc1ccc2c(CC(O)=O)c([nH]c2c1)C(=O)c1cc(C)ccn1 Show InChI InChI=1S/C18H16N2O4/c1-10-5-6-19-15(7-10)18(23)17-13(9-16(21)22)12-4-3-11(24-2)8-14(12)20-17/h3-8,20H,9H2,1-2H3,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of COX-2-mediated 6-keto-PGF1alpha production in IL-1beta-induced HUVEC preincubated for 20 mins prior A23187 stimulation measured after 1...				Eur J Med Chem 50: 179-95 (2012) Article DOI: 10.1016/j.ejmech.2012.01.053 BindingDB Entry DOI: 10.7270/Q2B27VR8
					More data for this Ligand-Target Pair