null

SMILES: O=c1cc(cc[nH]1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12

InChI Key: InChIKey=YFJPSLNOMOYYLM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50365788   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 5 (Homo sapiens (Human))	BDBM50365788 (CHEMBL1956567) Show SMILES O=c1cc(cc[nH]1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12 Show InChI InChI=1S/C21H20N6O2/c28-19-13-15(5-6-22-19)18-14-24-20(21-23-7-8-27(18)21)25-16-1-3-17(4-2-16)26-9-11-29-12-10-26/h1-8,13-14H,9-12H2,(H,22,28)(H,24,25)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	871	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos NV Curated by ChEMBL					Assay Description Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...				Bioorg Med Chem Lett 22: 2266-70 (2012) Article DOI: 10.1016/j.bmcl.2012.01.077 BindingDB Entry DOI: 10.7270/Q2CR5TT6
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 5 (Homo sapiens (Human))	BDBM50365788 (CHEMBL1956567) Show SMILES O=c1cc(cc[nH]1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12 Show InChI InChI=1S/C21H20N6O2/c28-19-13-15(5-6-22-19)18-14-24-20(21-23-7-8-27(18)21)25-16-1-3-17(4-2-16)26-9-11-29-12-10-26/h1-8,13-14H,9-12H2,(H,22,28)(H,24,25)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos NV Curated by ChEMBL					Assay Description Inhibition of MAPKAPK5				Bioorg Med Chem Lett 22: 2266-70 (2012) Article DOI: 10.1016/j.bmcl.2012.01.077 BindingDB Entry DOI: 10.7270/Q2CR5TT6
					More data for this Ligand-Target Pair