null

SMILES: NC(=O)c1cc(cs1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12

InChI Key: InChIKey=XXKMGNYNRUVACE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50365794   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 5 (Homo sapiens (Human))	BDBM50365794 (CHEMBL1956573) Show SMILES NC(=O)c1cc(cs1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12 Show InChI InChI=1S/C21H20N6O2S/c22-19(28)18-11-14(13-30-18)17-12-24-20(21-23-5-6-27(17)21)25-15-1-3-16(4-2-15)26-7-9-29-10-8-26/h1-6,11-13H,7-10H2,(H2,22,28)(H,24,25)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	327	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos NV Curated by ChEMBL					Assay Description Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...				Bioorg Med Chem Lett 22: 2266-70 (2012) Article DOI: 10.1016/j.bmcl.2012.01.077 BindingDB Entry DOI: 10.7270/Q2CR5TT6
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 5 (Homo sapiens (Human))	BDBM50365794 (CHEMBL1956573) Show SMILES NC(=O)c1cc(cs1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12 Show InChI InChI=1S/C21H20N6O2S/c22-19(28)18-11-14(13-30-18)17-12-24-20(21-23-5-6-27(17)21)25-15-1-3-16(4-2-15)26-7-9-29-10-8-26/h1-6,11-13H,7-10H2,(H2,22,28)(H,24,25)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	437	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos NV Curated by ChEMBL					Assay Description Inhibition of MAPKAPK5				Bioorg Med Chem Lett 22: 2266-70 (2012) Article DOI: 10.1016/j.bmcl.2012.01.077 BindingDB Entry DOI: 10.7270/Q2CR5TT6
					More data for this Ligand-Target Pair