null

SMILES: C1CN(CCO1)c1ccc(Nc2ncc(-c3cn[nH]c3)n3ncnc23)cc1

InChI Key: InChIKey=WSPYBPVYCFYIRM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50365800   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 5 (Homo sapiens (Human))	BDBM50365800 (CHEMBL1956687) Show SMILES C1CN(CCO1)c1ccc(Nc2ncc(-c3cn[nH]c3)n3ncnc23)cc1 Show InChI InChI=1S/C18H18N8O/c1-3-15(25-5-7-27-8-6-25)4-2-14(1)24-17-18-20-12-23-26(18)16(11-19-17)13-9-21-22-10-13/h1-4,9-12H,5-8H2,(H,19,24)(H,21,22)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos NV Curated by ChEMBL					Assay Description Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...				Bioorg Med Chem Lett 22: 2266-70 (2012) Article DOI: 10.1016/j.bmcl.2012.01.077 BindingDB Entry DOI: 10.7270/Q2CR5TT6
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 5 (Homo sapiens (Human))	BDBM50365800 (CHEMBL1956687) Show SMILES C1CN(CCO1)c1ccc(Nc2ncc(-c3cn[nH]c3)n3ncnc23)cc1 Show InChI InChI=1S/C18H18N8O/c1-3-15(25-5-7-27-8-6-25)4-2-14(1)24-17-18-20-12-23-26(18)16(11-19-17)13-9-21-22-10-13/h1-4,9-12H,5-8H2,(H,19,24)(H,21,22)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	816	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos NV Curated by ChEMBL					Assay Description Inhibition of MAPKAPK5				Bioorg Med Chem Lett 22: 2266-70 (2012) Article DOI: 10.1016/j.bmcl.2012.01.077 BindingDB Entry DOI: 10.7270/Q2CR5TT6
					More data for this Ligand-Target Pair