BDBM50365979 CHEMBL1956250
SMILES: COc1cc2nncc(-c3cnc(N4CCC(CC4)C(C)(C)O)c(C)c3)c2cc1OC
InChI Key: InChIKey=PPAWFHDEPAUENY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50365979 (CHEMBL1956250) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of PDE10A | Bioorg Med Chem Lett 22: 2262-5 (2012) Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |