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SMILES: Nc1nc(Nc2cccc(Br)c2)c2ccn(Cc3cccc4ccccc34)c2n1

InChI Key: InChIKey=XETBAKDIRRDIRG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50366084   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50366084 (CHEMBL1956895) Show SMILES Nc1nc(Nc2cccc(Br)c2)c2ccn(Cc3cccc4ccccc34)c2n1 Show InChI InChI=1S/C23H18BrN5/c24-17-8-4-9-18(13-17)26-21-20-11-12-29(22(20)28-23(25)27-21)14-16-7-3-6-15-5-1-2-10-19(15)16/h1-13H,14H2,(H3,25,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of EGF-induced EGFR autophosphorylation in human A431 cells incubated for 60 mins prior to EGF-induction measured after 10 mins by phospho...				Bioorg Med Chem 20: 2444-54 (2012) Article DOI: 10.1016/j.bmc.2012.01.029 BindingDB Entry DOI: 10.7270/Q2XK8G14
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50366084 (CHEMBL1956895) Show SMILES Nc1nc(Nc2cccc(Br)c2)c2ccn(Cc3cccc4ccccc34)c2n1 Show InChI InChI=1S/C23H18BrN5/c24-17-8-4-9-18(13-17)26-21-20-11-12-29(22(20)28-23(25)27-21)14-16-7-3-6-15-5-1-2-10-19(15)16/h1-13H,14H2,(H3,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of PDGFBB-induced PDGFRbeta autophosphorylation in human SF539 cells incubated for 60 mins prior to PDGFBB-induction measured after 10 min...				Bioorg Med Chem 20: 2444-54 (2012) Article DOI: 10.1016/j.bmc.2012.01.029 BindingDB Entry DOI: 10.7270/Q2XK8G14
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50366084 (CHEMBL1956895) Show SMILES Nc1nc(Nc2cccc(Br)c2)c2ccn(Cc3cccc4ccccc34)c2n1 Show InChI InChI=1S/C23H18BrN5/c24-17-8-4-9-18(13-17)26-21-20-11-12-29(22(20)28-23(25)27-21)14-16-7-3-6-15-5-1-2-10-19(15)16/h1-13H,14H2,(H3,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.49E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGF-induced VEGFR2 autophosphorylation in human U251 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...				Bioorg Med Chem 20: 2444-54 (2012) Article DOI: 10.1016/j.bmc.2012.01.029 BindingDB Entry DOI: 10.7270/Q2XK8G14
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50366084 (CHEMBL1956895) Show SMILES Nc1nc(Nc2cccc(Br)c2)c2ccn(Cc3cccc4ccccc34)c2n1 Show InChI InChI=1S/C23H18BrN5/c24-17-8-4-9-18(13-17)26-21-20-11-12-29(22(20)28-23(25)27-21)14-16-7-3-6-15-5-1-2-10-19(15)16/h1-13H,14H2,(H3,25,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGF-induced VEGFR1 autophosphorylation in human A498 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...				Bioorg Med Chem 20: 2444-54 (2012) Article DOI: 10.1016/j.bmc.2012.01.029 BindingDB Entry DOI: 10.7270/Q2XK8G14
					More data for this Ligand-Target Pair