BDBM50366818 CHEMBL1202833

SMILES: COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(NCc3ccccn3)nc2c(=O)n1Cc1ccnc(C)c1

InChI Key: InChIKey=UPLRGVQPKVXGDU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50366818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50366818 (CHEMBL1202833) Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(NCc3ccccn3)nc2c(=O)n1Cc1ccnc(C)c1 Show InChI InChI=1S/C32H31N5O6/c1-19-14-20(11-13-33-19)18-37-29(32(39)43-5)27(21-15-24(40-2)30(42-4)25(16-21)41-3)23-9-10-26(36-28(23)31(37)38)35-17-22-8-6-7-12-34-22/h6-16H,17-18H2,1-5H3,(H,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lung				Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50366818 (CHEMBL1202833) Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(NCc3ccccn3)nc2c(=O)n1Cc1ccnc(C)c1 Show InChI InChI=1S/C32H31N5O6/c1-19-14-20(11-13-33-19)18-37-29(32(39)43-5)27(21-15-24(40-2)30(42-4)25(16-21)41-3)23-9-10-26(36-28(23)31(37)38)35-17-22-8-6-7-12-34-22/h6-16H,17-18H2,1-5H3,(H,35,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase-1 (PDE1) isolated from canine lung				Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2
					More data for this Ligand-Target Pair
Phosphodiesterase 6 (Bos taurus-Bos taurus (Bovine))	BDBM50366818 (CHEMBL1202833) Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(NCc3ccccn3)nc2c(=O)n1Cc1ccnc(C)c1 Show InChI InChI=1S/C32H31N5O6/c1-19-14-20(11-13-33-19)18-37-29(32(39)43-5)27(21-15-24(40-2)30(42-4)25(16-21)41-3)23-9-10-26(36-28(23)31(37)38)35-17-22-8-6-7-12-34-22/h6-16H,17-18H2,1-5H3,(H,35,36)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 6 isolated from bovine retina				Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2
					More data for this Ligand-Target Pair