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BDBM50370219 CHEMBL610868

SMILES: Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OC6[C@H](O)[C@@H](COP(O)(O)=O)OC6n6c(N=[N+]=[N-])nc7c(N)ncnc67)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12

InChI Key: InChIKey=XHIKJSKQFMFXAJ-JZEHZVHESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50370219   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RNase L


(Mus musculus)		BDBM50370219
PNG
(CHEMBL610868)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OC6[C@H](O)[C@@H](COP(O)(O)=O)OC6n6c(N=[N+]=[N-])nc7c(N)ncnc67)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12 |r|
Show InChI InChI=1S/C40H46N32O25P4/c41-25-13-29(53-5-49-25)69(37(57-13)61-65-45)33-21(77)17(73)9(91-33)2-88-99(81,82)96-23-19(75)11(93-35(23)71-31-15(27(43)51-7-55-31)59-39(71)63-67-47)4-90-101(85,86)97-24-20(76)12(94-36(24)72-32-16(28(44)52-8-56-32)60-40(72)64-68-48)3-89-100(83,84)95-22-18(74)10(1-87-98(78,79)80)92-34(22)70-30-14(26(42)50-6-54-30)58-38(70)62-66-46/h5-12,17-24,33-36,73-77H,1-4H2,(H,81,82)(H,83,84)(H,85,86)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)(H2,78,79,80)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22?,23-,24-,33?,34?,35?,36?/m1/s1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
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UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver

J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair