Found 6 hits for monomerid = 50372155 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372155
(CHEMBL255956)Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)cc1 Show InChI InChI=1S/C20H18N6O/c1-12-2-6-14(7-3-12)23-20(27)24-15-8-4-13(5-9-15)16-10-11-22-19-17(16)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells |
Bioorg Med Chem Lett 18: 386-90 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372155
(CHEMBL255956)Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)cc1 Show InChI InChI=1S/C20H18N6O/c1-12-2-6-14(7-3-12)23-20(27)24-15-8-4-13(5-9-15)16-10-11-22-19-17(16)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR by HTRF assay |
Bioorg Med Chem Lett 18: 386-90 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372155
(CHEMBL255956)Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)cc1 Show InChI InChI=1S/C20H18N6O/c1-12-2-6-14(7-3-12)23-20(27)24-15-8-4-13(5-9-15)16-10-11-22-19-17(16)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of KDR (unknown origin) in cell-based assay |
Citation and Details
Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372155
(CHEMBL255956)Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)cc1 Show InChI InChI=1S/C20H18N6O/c1-12-2-6-14(7-3-12)23-20(27)24-15-8-4-13(5-9-15)16-10-11-22-19-17(16)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of KDR kinase activity (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372155
(CHEMBL255956)Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)cc1 Show InChI InChI=1S/C20H18N6O/c1-12-2-6-14(7-3-12)23-20(27)24-15-8-4-13(5-9-15)16-10-11-22-19-17(16)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of KDR kinase activity (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372155
(CHEMBL255956)Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2ccnc3[nH]nc(N)c23)cc1 Show InChI InChI=1S/C20H18N6O/c1-12-2-6-14(7-3-12)23-20(27)24-15-8-4-13(5-9-15)16-10-11-22-19-17(16)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of KDR (unknown origin) in cell-based assay |
Citation and Details
Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT |
More data for this Ligand-Target Pair | |