BDBM50372157 CHEMBL257292

SMILES: Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1ccnc2[nH]nc(N)c12

InChI Key: InChIKey=NXYRUIDMZGFWFN-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50372157   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372157 (CHEMBL257292) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1ccnc2[nH]nc(N)c12 Show InChI InChI=1S/C20H18N6O/c1-12-4-2-3-5-16(12)24-20(27)23-14-8-6-13(7-9-14)15-10-11-22-19-17(15)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372157 (CHEMBL257292) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1ccnc2[nH]nc(N)c12 Show InChI InChI=1S/C20H18N6O/c1-12-4-2-3-5-16(12)24-20(27)23-14-8-6-13(7-9-14)15-10-11-22-19-17(15)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372157 (CHEMBL257292) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1ccnc2[nH]nc(N)c12 Show InChI InChI=1S/C20H18N6O/c1-12-4-2-3-5-16(12)24-20(27)23-14-8-6-13(7-9-14)15-10-11-22-19-17(15)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KDR (unknown origin) in cell-based assay				Citation and Details Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372157 (CHEMBL257292) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1ccnc2[nH]nc(N)c12 Show InChI InChI=1S/C20H18N6O/c1-12-4-2-3-5-16(12)24-20(27)23-14-8-6-13(7-9-14)15-10-11-22-19-17(15)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KDR kinase activity (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372157 (CHEMBL257292) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1ccnc2[nH]nc(N)c12 Show InChI InChI=1S/C20H18N6O/c1-12-4-2-3-5-16(12)24-20(27)23-14-8-6-13(7-9-14)15-10-11-22-19-17(15)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KDR kinase activity (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372157 (CHEMBL257292) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1ccnc2[nH]nc(N)c12 Show InChI InChI=1S/C20H18N6O/c1-12-4-2-3-5-16(12)24-20(27)23-14-8-6-13(7-9-14)15-10-11-22-19-17(15)18(21)25-26-19/h2-11H,1H3,(H2,23,24,27)(H3,21,22,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KDR (unknown origin) in cell-based assay				Citation and Details Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT
					More data for this Ligand-Target Pair