BindingDB PrimarySearch

BDBM50372158 CHEMBL404367

SMILES: Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cncc3n(C)nc(N)c23)c1

InChI Key: InChIKey=GEGCXGMFUYJULA-UHFFFAOYSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50372158
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of cKit by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FYN by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of SRC by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT1 by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KDR kinase activity (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT
TBA					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KDR (unknown origin) in cell-based assay				Citation and Details Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT
TBA					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KDR (unknown origin) in cell-based assay				Citation and Details Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT
TBA					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KDR kinase activity (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9926-4 BindingDB Entry DOI: 10.7270/Q2W66PNT
TBA					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50372158 (CHEMBL404367) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of CSF1R by HTRF assay				Bioorg Med Chem Lett 18: 386-90 (2008) Article DOI: 10.1016/j.bmcl.2007.10.018 BindingDB Entry DOI: 10.7270/Q21837B6
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair