BDBM50372496 CHEMBL273149
SMILES: COc1cc2ccc(C)nc2c2NS(=O)(=O)c3ccc(C)cc3-c12
InChI Key: InChIKey=UXHUBTDSTIIYHF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
I-kappa-B-alpha (Homo sapiens (Human)) | BDBM50372496 (CHEMBL273149) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
Columbia University Curated by ChEMBL | Assay Description Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assay | Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
I-kappa-B-alpha (Homo sapiens (Human)) | BDBM50372496 (CHEMBL273149) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a |
Columbia University Curated by ChEMBL | Assay Description Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r... | Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear factor NF-kappa-B (Homo sapiens (Human)) | BDBM50372496 (CHEMBL273149) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University Curated by ChEMBL | Assay Description Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC | Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63 | |||||||||||
More data for this Ligand-Target Pair |