BDBM50373783 CHEMBL255136

SMILES: Oc1ccc(cc1)-c1cc(NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)c(=O)n(CC(F)(F)F)c1

InChI Key: InChIKey=HVKODJSGQZTNDF-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50373783   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50373783 (CHEMBL255136) Show SMILES Oc1ccc(cc1)-c1cc(NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)c(=O)n(CC(F)(F)F)c1 Show InChI InChI=1S/C25H23F3N6O4/c26-25(27,28)14-33-13-16(15-3-5-18(35)6-4-15)12-19(22(33)36)30-23(37)32-10-7-17(8-11-32)34-20-2-1-9-29-21(20)31-24(34)38/h1-6,9,12-13,17,35H,7-8,10-11,14H2,(H,30,37)(H,29,31,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	96	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]CGRP from human recombinant CL receptor /RAMP1				Bioorg Med Chem Lett 18: 755-8 (2008) Article DOI: 10.1016/j.bmcl.2007.11.042 BindingDB Entry DOI: 10.7270/Q2T43TZ2
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50373783 (CHEMBL255136) Show SMILES Oc1ccc(cc1)-c1cc(NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)c(=O)n(CC(F)(F)F)c1 Show InChI InChI=1S/C25H23F3N6O4/c26-25(27,28)14-33-13-16(15-3-5-18(35)6-4-15)12-19(22(33)36)30-23(37)32-10-7-17(8-11-32)34-20-2-1-9-29-21(20)31-24(34)38/h1-6,9,12-13,17,35H,7-8,10-11,14H2,(H,30,37)(H,29,31,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	971	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based ...				Bioorg Med Chem Lett 18: 755-8 (2008) Article DOI: 10.1016/j.bmcl.2007.11.042 BindingDB Entry DOI: 10.7270/Q2T43TZ2
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50373783 (CHEMBL255136) Show SMILES Oc1ccc(cc1)-c1cc(NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)c(=O)n(CC(F)(F)F)c1 Show InChI InChI=1S/C25H23F3N6O4/c26-25(27,28)14-33-13-16(15-3-5-18(35)6-4-15)12-19(22(33)36)30-23(37)32-10-7-17(8-11-32)34-20-2-1-9-29-21(20)31-24(34)38/h1-6,9,12-13,17,35H,7-8,10-11,14H2,(H,30,37)(H,29,31,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	282	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay				Bioorg Med Chem Lett 18: 755-8 (2008) Article DOI: 10.1016/j.bmcl.2007.11.042 BindingDB Entry DOI: 10.7270/Q2T43TZ2
					More data for this Ligand-Target Pair