BDBM50375148 CHEMBL257665

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)C2CC3CCC2C3)cc1

InChI Key: InChIKey=RZUCEFAFHFOZJN-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50375148   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50375148 (CHEMBL257665) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)C2CC3CCC2C3)cc1 |w:31.33,28.31,26.28,TEB:18:26:29.30:32| Show InChI InChI=1S/C26H31N7O2/c1-31-8-10-32(11-9-31)19-6-4-18(5-7-19)29-26-28-14-20-23(34)21(24(27)35)15-33(25(20)30-26)22-13-16-2-3-17(22)12-16/h4-7,14-17,22H,2-3,8-13H2,1H3,(H2,27,35)(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of ATP-induced CSF1R autophosphorylation				Bioorg Med Chem Lett 18: 2355-61 (2008) Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3
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