Found 8 hits for monomerid = 50375155 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage colony stimulating factor receptor
(Homo sapiens (Human)) | BDBM50375155
(CHEMBL256893)Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of CSF1R |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50375155
(CHEMBL256893)Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of FLT3 |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50375155
(CHEMBL256893)Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of KIT |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50375155
(CHEMBL256893)Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of Axl |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50375155
(CHEMBL256893)Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of TrkA |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375155
(CHEMBL256893)Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of Src |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Macrophage colony stimulating factor receptor
(Homo sapiens (Human)) | BDBM50375155
(CHEMBL256893)Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of ATP-induced CSF1R autophosphorylation |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50375155
(CHEMBL256893)Show SMILES CN1CCN(Cc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1 Show InChI InChI=1S/C29H31N7O2/c1-34-11-13-35(14-12-34)17-19-5-8-22(9-6-19)32-29-31-16-24-26(37)25(27(30)38)18-36(28(24)33-29)23-10-7-20-3-2-4-21(20)15-23/h5-10,15-16,18H,2-4,11-14,17H2,1H3,(H2,30,38)(H,31,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |