BDBM50375333 CHEMBL430051

SMILES: CN(C)[C@H]1C[C@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12

InChI Key: InChIKey=FJFLEPJNZGVFDM-OYRHEFFESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50375333   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50375333 (CHEMBL430051) Show SMILES CN(C)[C@H]1C[C@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 |wU:5.7,3.2,(24.37,-53.29,;25.4,-52.15,;26.9,-52.47,;24.92,-50.68,;23.55,-49.98,;24.24,-48.62,;25.62,-49.31,;23.77,-47.15,;24.68,-45.9,;23.76,-44.64,;24.54,-43.32,;23.78,-41.99,;24.55,-40.66,;26.09,-40.66,;26.86,-39.32,;28.4,-39.34,;29.18,-40.67,;28.4,-42.01,;26.86,-42,;26.08,-43.33,;30.72,-40.68,;31.49,-42.02,;33.03,-42.02,;33.8,-40.68,;33.02,-39.34,;31.49,-39.35,;22.29,-45.12,;20.95,-44.36,;20.94,-42.82,;19.62,-45.13,;19.62,-46.67,;20.95,-47.44,;22.29,-46.67,)| Show InChI InChI=1S/C27H26N6/c1-32(2)21-14-20(15-21)27-31-24(25-26(28)29-12-13-33(25)27)19-9-8-18-10-11-22(30-23(18)16-19)17-6-4-3-5-7-17/h3-13,16,20-21H,14-15H2,1-2H3,(H2,28,29)/t20-,21+	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells				Bioorg Med Chem 16: 1359-75 (2008) Article DOI: 10.1016/j.bmc.2007.10.061 BindingDB Entry DOI: 10.7270/Q2WH2QVH
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50375333 (CHEMBL430051) Show SMILES CN(C)[C@H]1C[C@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 |wU:5.7,3.2,(24.37,-53.29,;25.4,-52.15,;26.9,-52.47,;24.92,-50.68,;23.55,-49.98,;24.24,-48.62,;25.62,-49.31,;23.77,-47.15,;24.68,-45.9,;23.76,-44.64,;24.54,-43.32,;23.78,-41.99,;24.55,-40.66,;26.09,-40.66,;26.86,-39.32,;28.4,-39.34,;29.18,-40.67,;28.4,-42.01,;26.86,-42,;26.08,-43.33,;30.72,-40.68,;31.49,-42.02,;33.03,-42.02,;33.8,-40.68,;33.02,-39.34,;31.49,-39.35,;22.29,-45.12,;20.95,-44.36,;20.94,-42.82,;19.62,-45.13,;19.62,-46.67,;20.95,-47.44,;22.29,-46.67,)| Show InChI InChI=1S/C27H26N6/c1-32(2)21-14-20(15-21)27-31-24(25-26(28)29-12-13-33(25)27)19-9-8-18-10-11-22(30-23(18)16-19)17-6-4-3-5-7-17/h3-13,16,20-21H,14-15H2,1-2H3,(H2,28,29)/t20-,21+	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem 16: 1359-75 (2008) Article DOI: 10.1016/j.bmc.2007.10.061 BindingDB Entry DOI: 10.7270/Q2WH2QVH
					More data for this Ligand-Target Pair