BDBM50375575 CHEMBL270493
SMILES: C[C@H](CCC(=O)NCCS(O)(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](CC[C@]4(C)[C@H]3CC[C@]12C)OS(O)(=O)=O
InChI Key: InChIKey=HSNPMXROZIQAQD-GBURMNQMSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Multidrug resistance-associated protein 4 (Homo sapiens (Human)) | BDBM50375575 (CHEMBL270493) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Netherlands Cancer Institute Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing HEK-293 cells | Biochem J 371: 361-7 (2003) Article DOI: 10.1042/BJ20021886 BindingDB Entry DOI: 10.7270/Q2GH9K68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Rattus norvegicus) | BDBM50375575 (CHEMBL270493) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of Taurocholate uptake (Taurocholate: 1 uM) in membrane vesicles isolated from Bsep-expressing Sf9 cells | Biochim Biophys Acta 1511: 7-16 (2001) BindingDB Entry DOI: 10.7270/Q2KW5H4R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Rattus norvegicus) | BDBM50375575 (CHEMBL270493) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of Taurocholate uptake (Taurocholate: 1 uM) in canalicular membrane vesicles from SD rat | Biochim Biophys Acta 1511: 7-16 (2001) BindingDB Entry DOI: 10.7270/Q2KW5H4R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled bile acid receptor 1 (Homo sapiens (Human)) | BDBM50375575 (CHEMBL270493) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.78E+4 | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Agonist activity at human TGR5 expressed in CHO cells by luciferase assay | J Med Chem 51: 1831-41 (2008) Article DOI: 10.1021/jm7015864 BindingDB Entry DOI: 10.7270/Q2222VNJ | |||||||||||
More data for this Ligand-Target Pair |