BDBM50376027 CHEMBL272693

SMILES: COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC

InChI Key: InChIKey=PHUIVAKJVUJLDO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50376027   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50376027 (CHEMBL272693) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC Show InChI InChI=1S/C27H21N3O4/c1-32-25-15-22-23(16-26(25)33-2)29-13-10-24(22)34-19-6-7-20-17(14-19)4-3-5-21(20)27(31)30-18-8-11-28-12-9-18/h3-16H,1-2H3,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				J Med Chem 51: 1649-67 (2008) Article DOI: 10.1021/jm701097z BindingDB Entry DOI: 10.7270/Q29C6Z8N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50376027 (CHEMBL272693) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC Show InChI InChI=1S/C27H21N3O4/c1-32-25-15-22-23(16-26(25)33-2)29-13-10-24(22)34-19-6-7-20-17(14-19)4-3-5-21(20)27(31)30-18-8-11-28-12-9-18/h3-16H,1-2H3,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Lanzhou University Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 after 60 mins				J Mol Graph Model 27: 642-54 (2008) Article DOI: 10.1016/j.jmgm.2008.10.006 BindingDB Entry DOI: 10.7270/Q2C24XNX
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50376027 (CHEMBL272693) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC Show InChI InChI=1S/C27H21N3O4/c1-32-25-15-22-23(16-26(25)33-2)29-13-10-24(22)34-19-6-7-20-17(14-19)4-3-5-21(20)27(31)30-18-8-11-28-12-9-18/h3-16H,1-2H3,(H,28,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CYP2D6				J Med Chem 51: 1649-67 (2008) Article DOI: 10.1021/jm701097z BindingDB Entry DOI: 10.7270/Q29C6Z8N
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50376027 (CHEMBL272693) Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC Show InChI InChI=1S/C27H21N3O4/c1-32-25-15-22-23(16-26(25)33-2)29-13-10-24(22)34-19-6-7-20-17(14-19)4-3-5-21(20)27(31)30-18-8-11-28-12-9-18/h3-16H,1-2H3,(H,28,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 51: 1649-67 (2008) Article DOI: 10.1021/jm701097z BindingDB Entry DOI: 10.7270/Q29C6Z8N
					More data for this Ligand-Target Pair