BDBM50376417 CHEMBL261865
SMILES: [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1
InChI Key: InChIKey=XGAPMFLSMNOPPE-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor VIII (Homo sapiens (Human)) | BDBM50376417 (CHEMBL261865) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University Curated by ChEMBL | Assay Description Inhibition of human factor 8 binding to immobilized phospholipid by surface plasmon resonance assay | Proc Natl Acad Sci USA 104: 12697-702 (2007) Article DOI: 10.1073/pnas.0701051104 BindingDB Entry DOI: 10.7270/Q2F190MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor V (Homo sapiens (Human)) | BDBM50376417 (CHEMBL261865) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University Curated by ChEMBL | Assay Description Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay | Proc Natl Acad Sci USA 104: 12697-702 (2007) Article DOI: 10.1073/pnas.0701051104 BindingDB Entry DOI: 10.7270/Q2F190MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor V (Homo sapiens (Human)) | BDBM50376417 (CHEMBL261865) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University Curated by ChEMBL | Assay Description Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay | Proc Natl Acad Sci USA 104: 12697-702 (2007) Article DOI: 10.1073/pnas.0701051104 BindingDB Entry DOI: 10.7270/Q2F190MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor V (Homo sapiens (Human)) | BDBM50376417 (CHEMBL261865) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University Curated by ChEMBL | Assay Description Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay | Proc Natl Acad Sci USA 104: 12697-702 (2007) Article DOI: 10.1073/pnas.0701051104 BindingDB Entry DOI: 10.7270/Q2F190MG | |||||||||||
More data for this Ligand-Target Pair |