BDBM50376472 CHEMBL259053

SMILES: FC(F)(F)c1cc2NC(=O)CC(=Nc2cc1Cl)c1cccc(c1)-n1ccnn1

InChI Key: InChIKey=PXTUROXJUIVEOU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50376472   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50376472 (CHEMBL259053) Show SMILES FC(F)(F)c1cc2NC(=O)CC(=Nc2cc1Cl)c1cccc(c1)-n1ccnn1 |c:11| Show InChI InChI=1S/C18H11ClF3N5O/c19-13-8-16-15(7-12(13)18(20,21)22)25-17(28)9-14(24-16)10-2-1-3-11(6-10)27-5-4-23-26-27/h1-8H,9H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production				Bioorg Med Chem Lett 18: 2725-9 (2008) Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50376472 (CHEMBL259053) Show SMILES FC(F)(F)c1cc2NC(=O)CC(=Nc2cc1Cl)c1cccc(c1)-n1ccnn1 |c:11| Show InChI InChI=1S/C18H11ClF3N5O/c19-13-8-16-15(7-12(13)18(20,21)22)25-17(28)9-14(24-16)10-2-1-3-11(6-10)27-5-4-23-26-27/h1-8H,9H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]LY354740 from rat mGluR2				Bioorg Med Chem Lett 18: 2725-9 (2008) Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D
					More data for this Ligand-Target Pair