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BDBM50377347 CHEMBL404640

SMILES: COc1ccc(-c2cc(C)c3NC(C)(C)CC(C)c3c2Cl)c2[nH]ccc12

InChI Key: InChIKey=NZGNOGXYEWYRJB-UHFFFAOYSA-N

Data: 2 KI 2 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50377347
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50377347 (CHEMBL404640) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of radiolabeled Dexamethasone from glucocorticoid receptor				Bioorg Med Chem Lett 18: 3504-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.029 BindingDB Entry DOI: 10.7270/Q2CR5V8F
Ligand Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50377347 (CHEMBL404640) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity at progesterone receptor				Bioorg Med Chem Lett 18: 3504-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.029 BindingDB Entry DOI: 10.7270/Q2CR5V8F
Ligand Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50377347 (CHEMBL404640) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression				Bioorg Med Chem Lett 18: 3504-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.029 BindingDB Entry DOI: 10.7270/Q2CR5V8F
Ligand Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50377347 (CHEMBL404640) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...				Bioorg Med Chem Lett 18: 3504-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.029 BindingDB Entry DOI: 10.7270/Q2CR5V8F
Ligand Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50377347 (CHEMBL404640) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay				Bioorg Med Chem Lett 18: 3504-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.029 BindingDB Entry DOI: 10.7270/Q2CR5V8F
Ligand Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair