BDBM50377667 CHEMBL257778

SMILES: CC(=O)Cn1nnc(CNC(=O)c2ccc(cc2)-c2ccccc2)n1

InChI Key: InChIKey=YZPUPTZNEATUKA-UHFFFAOYSA-N

Data: 2 KI  2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50377667   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50377667 (CHEMBL257778) Show SMILES CC(=O)Cn1nnc(CNC(=O)c2ccc(cc2)-c2ccccc2)n1 Show InChI InChI=1S/C18H17N5O2/c1-13(24)12-23-21-17(20-22-23)11-19-18(25)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,19,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Binding affinity to human CB2 receptor expressed in COS cells				Bioorg Med Chem Lett 18: 2820-4 (2008) Article DOI: 10.1016/j.bmcl.2008.04.003 BindingDB Entry DOI: 10.7270/Q22808H1
					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50377667 (CHEMBL257778) Show SMILES CC(=O)Cn1nnc(CNC(=O)c2ccc(cc2)-c2ccccc2)n1 Show InChI InChI=1S/C18H17N5O2/c1-13(24)12-23-21-17(20-22-23)11-19-18(25)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,19,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Binding affinity to human CB1 receptor expressed in COS cells				Bioorg Med Chem Lett 18: 2820-4 (2008) Article DOI: 10.1016/j.bmcl.2008.04.003 BindingDB Entry DOI: 10.7270/Q22808H1
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50377667 (CHEMBL257778) Show SMILES CC(=O)Cn1nnc(CNC(=O)c2ccc(cc2)-c2ccccc2)n1 Show InChI InChI=1S/C18H17N5O2/c1-13(24)12-23-21-17(20-22-23)11-19-18(25)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,19,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux				Bioorg Med Chem Lett 18: 2820-4 (2008) Article DOI: 10.1016/j.bmcl.2008.04.003 BindingDB Entry DOI: 10.7270/Q22808H1
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50377667 (CHEMBL257778) Show SMILES CC(=O)Cn1nnc(CNC(=O)c2ccc(cc2)-c2ccccc2)n1 Show InChI InChI=1S/C18H17N5O2/c1-13(24)12-23-21-17(20-22-23)11-19-18(25)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,19,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux				Bioorg Med Chem Lett 18: 2820-4 (2008) Article DOI: 10.1016/j.bmcl.2008.04.003 BindingDB Entry DOI: 10.7270/Q22808H1
					More data for this Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha (Homo sapiens (Human))	BDBM50377667 (CHEMBL257778) Show SMILES CC(=O)Cn1nnc(CNC(=O)c2ccc(cc2)-c2ccccc2)n1 Show InChI InChI=1S/C18H17N5O2/c1-13(24)12-23-21-17(20-22-23)11-19-18(25)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,19,25)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell				Bioorg Med Chem Lett 18: 2820-4 (2008) Article DOI: 10.1016/j.bmcl.2008.04.003 BindingDB Entry DOI: 10.7270/Q22808H1
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50377667 (CHEMBL257778) Show SMILES CC(=O)Cn1nnc(CNC(=O)c2ccc(cc2)-c2ccccc2)n1 Show InChI InChI=1S/C18H17N5O2/c1-13(24)12-23-21-17(20-22-23)11-19-18(25)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,19,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis				Bioorg Med Chem Lett 18: 2820-4 (2008) Article DOI: 10.1016/j.bmcl.2008.04.003 BindingDB Entry DOI: 10.7270/Q22808H1
					More data for this Ligand-Target Pair