BDBM50377735 CHEMBL257779

SMILES: Cn1c(nnc1-c1cccc2n(C)ccc12)-c1ccccc1C(F)(F)F

InChI Key: InChIKey=NTNLPJLHGXIPQN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50377735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50377735 (CHEMBL257779) Show SMILES Cn1c(nnc1-c1cccc2n(C)ccc12)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-25-11-10-12-13(7-5-9-16(12)25)17-23-24-18(26(17)2)14-6-3-4-8-15(14)19(20,21)22/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells				Bioorg Med Chem Lett 18: 2799-804 (2008) Article DOI: 10.1016/j.bmcl.2008.04.010 BindingDB Entry DOI: 10.7270/Q2J9678F
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50377735 (CHEMBL257779) Show SMILES Cn1c(nnc1-c1cccc2n(C)ccc12)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-25-11-10-12-13(7-5-9-16(12)25)17-23-24-18(26(17)2)14-6-3-4-8-15(14)19(20,21)22/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells				Bioorg Med Chem Lett 18: 2799-804 (2008) Article DOI: 10.1016/j.bmcl.2008.04.010 BindingDB Entry DOI: 10.7270/Q2J9678F
					More data for this Ligand-Target Pair