BDBM50378008 CHEMBL1627314

SMILES: COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl

InChI Key: InChIKey=YRMKMEPMFOFXGH-UHFFFAOYSA-N

Data: 6 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50378008   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50378008 (CHEMBL1627314) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H28Cl2N4O3/c1-33-18-5-6-20-16(13-18)14-21(28-20)24(32)27-8-7-17(31)15-29-9-11-30(12-10-29)22-4-2-3-19(25)23(22)26/h2-6,13-14,17,28,31H,7-12,15H2,1H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells				J Med Chem 58: 5361-80 (2015) Article DOI: 10.1021/jm501512b BindingDB Entry DOI: 10.7270/Q2TX3H5Z
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50378008 (CHEMBL1627314) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H28Cl2N4O3/c1-33-18-5-6-20-16(13-18)14-21(28-20)24(32)27-8-7-17(31)15-29-9-11-30(12-10-29)22-4-2-3-19(25)23(22)26/h2-6,13-14,17,28,31H,7-12,15H2,1H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug AbuseIntramural Research Program Curated by ChEMBL					Assay Description Displacement of [125]IABN from human D3 receptor expressed in HEK293 cells				J Med Chem 52: 2559-70 (2009) Article DOI: 10.1021/jm900095y BindingDB Entry DOI: 10.7270/Q2HX1DKJ
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50378008 (CHEMBL1627314) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H28Cl2N4O3/c1-33-18-5-6-20-16(13-18)14-21(28-20)24(32)27-8-7-17(31)15-29-9-11-30(12-10-29)22-4-2-3-19(25)23(22)26/h2-6,13-14,17,28,31H,7-12,15H2,1H3,(H,27,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	217	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells				J Med Chem 58: 5361-80 (2015) Article DOI: 10.1021/jm501512b BindingDB Entry DOI: 10.7270/Q2TX3H5Z
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50378008 (CHEMBL1627314) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H28Cl2N4O3/c1-33-18-5-6-20-16(13-18)14-21(28-20)24(32)27-8-7-17(31)15-29-9-11-30(12-10-29)22-4-2-3-19(25)23(22)26/h2-6,13-14,17,28,31H,7-12,15H2,1H3,(H,27,32)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.04E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cells				J Med Chem 58: 5361-80 (2015) Article DOI: 10.1021/jm501512b BindingDB Entry DOI: 10.7270/Q2TX3H5Z
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50378008 (CHEMBL1627314) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H28Cl2N4O3/c1-33-18-5-6-20-16(13-18)14-21(28-20)24(32)27-8-7-17(31)15-29-9-11-30(12-10-29)22-4-2-3-19(25)23(22)26/h2-6,13-14,17,28,31H,7-12,15H2,1H3,(H,27,32)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug AbuseIntramural Research Program Curated by ChEMBL					Assay Description Displacement of [125]IABN from human D4 receptor expressed in HEK293 cells				J Med Chem 52: 2559-70 (2009) Article DOI: 10.1021/jm900095y BindingDB Entry DOI: 10.7270/Q2HX1DKJ
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50378008 (CHEMBL1627314) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H28Cl2N4O3/c1-33-18-5-6-20-16(13-18)14-21(28-20)24(32)27-8-7-17(31)15-29-9-11-30(12-10-29)22-4-2-3-19(25)23(22)26/h2-6,13-14,17,28,31H,7-12,15H2,1H3,(H,27,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug AbuseIntramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]SCH23390 from D1 receptor				J Med Chem 52: 2559-70 (2009) Article DOI: 10.1021/jm900095y BindingDB Entry DOI: 10.7270/Q2HX1DKJ
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50378008 (CHEMBL1627314) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NCCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H28Cl2N4O3/c1-33-18-5-6-20-16(13-18)14-21(28-20)24(32)27-8-7-17(31)15-29-9-11-30(12-10-29)22-4-2-3-19(25)23(22)26/h2-6,13-14,17,28,31H,7-12,15H2,1H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.51	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug AbuseIntramural Research Program Curated by ChEMBL					Assay Description Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis				J Med Chem 52: 2559-70 (2009) Article DOI: 10.1021/jm900095y BindingDB Entry DOI: 10.7270/Q2HX1DKJ
					More data for this Ligand-Target Pair