Found 4 hits for monomerid = 50378235 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
CDK2/Cyclin E/G1/S-specific cyclin E2
(Homo sapiens (Human)) | BDBM50378235
(CHEMBL461557)Show SMILES CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccc2)c2ncn(C(C)C)c2n1 |r| Show InChI InChI=1S/C25H30N6O/c1-4-21(15-32)28-25-29-23(22-24(30-25)31(16-27-22)17(2)3)26-14-18-10-12-20(13-11-18)19-8-6-5-7-9-19/h5-13,16-17,21,32H,4,14-15H2,1-3H3,(H2,26,28,29,30)/t21-/m1/s1 | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI
Curated by ChEMBL
| Assay Description
Inhibition of recombinant CDK2/cyclin E |
Bioorg Med Chem Lett 19: 6608-12 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.025
BindingDB Entry DOI: 10.7270/Q2445NFT |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase-3
(Sus scrofa) | BDBM50378235
(CHEMBL461557)Show SMILES CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccc2)c2ncn(C(C)C)c2n1 |r| Show InChI InChI=1S/C25H30N6O/c1-4-21(15-32)28-25-29-23(22-24(30-25)31(16-27-22)17(2)3)26-14-18-10-12-20(13-11-18)19-8-6-5-7-9-19/h5-13,16-17,21,32H,4,14-15H2,1-3H3,(H2,26,28,29,30)/t21-/m1/s1 | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Paris-Descartes
Curated by ChEMBL
| Assay Description
Inhibition of pig brain GSK3alpha/beta |
J Med Chem 51: 5229-42 (2008)
Article DOI: 10.1021/jm800109e
BindingDB Entry DOI: 10.7270/Q2DB84PF |
More data for this
Ligand-Target Pair | |
Voltage-gated calcium channel subunit alpha Cav2.2
(Homo sapiens (Human)) | BDBM50378235
(CHEMBL461557)Show SMILES CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccc2)c2ncn(C(C)C)c2n1 |r| Show InChI InChI=1S/C25H30N6O/c1-4-21(15-32)28-25-29-23(22-24(30-25)31(16-27-22)17(2)3)26-14-18-10-12-20(13-11-18)19-8-6-5-7-9-19/h5-13,16-17,21,32H,4,14-15H2,1-3H3,(H2,26,28,29,30)/t21-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp method |
ACS Med Chem Lett 3: 985-990 (2012)
Article DOI: 10.1021/ml3002083
BindingDB Entry DOI: 10.7270/Q2BC40P0 |
More data for this
Ligand-Target Pair | |
CDK2/Cyclin A/Cyclin A1
(Homo sapiens (Human)) | BDBM50378235
(CHEMBL461557)Show SMILES CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccc2)c2ncn(C(C)C)c2n1 |r| Show InChI InChI=1S/C25H30N6O/c1-4-21(15-32)28-25-29-23(22-24(30-25)31(16-27-22)17(2)3)26-14-18-10-12-20(13-11-18)19-8-6-5-7-9-19/h5-13,16-17,21,32H,4,14-15H2,1-3H3,(H2,26,28,29,30)/t21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI
Curated by ChEMBL
| Assay Description
Inhibition of recombinant CDK2/cyclin A |
Bioorg Med Chem Lett 19: 6608-12 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.025
BindingDB Entry DOI: 10.7270/Q2445NFT |
More data for this
Ligand-Target Pair | |
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