BDBM50379191 CHEMBL2011061

SMILES: CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12

InChI Key: InChIKey=DRYNJZPKJNJTOC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50379191   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50379191 (CHEMBL2011061) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)14-35-22-7-5-16(33-28-29-9-4-10-30-28)11-18(22)24-20-12-31-27(36)25(20)23-17(26(24)35)6-8-21-19(23)13-32-34(21)3/h4-5,7,9-11,13,15H,6,8,12,14H2,1-3H3,(H,31,36)(H,29,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50379191 (CHEMBL2011061) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cnn(C)c4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)14-35-22-7-5-16(33-28-29-9-4-10-30-28)11-18(22)24-20-12-31-27(36)25(20)23-17(26(24)35)6-8-21-19(23)13-32-34(21)3/h4-5,7,9-11,13,15H,6,8,12,14H2,1-3H3,(H,31,36)(H,29,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	241	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluoresce...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair