BDBM50379862 CHEMBL2011870
SMILES: COc1ccc(cc1)-c1nsc(NC(=O)[C@@H]2C[C@H]2C)c1C
InChI Key: InChIKey=HSEURPKENJFQMI-NOZJJQNGSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50379862 (CHEMBL2011870) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Negative allosteric modulation of human recombinant mGlu5 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in... | Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50379862 (CHEMBL2011870) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Negative allosteric modulation of human recombinant mGlu1 receptor expressed in Syrian hamster AV12 cells assessed as receptor-mediated changes in in... | Bioorg Med Chem Lett 23: 1249-52 (2013) Article DOI: 10.1016/j.bmcl.2013.01.009 BindingDB Entry DOI: 10.7270/Q2DJ5H0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (RAT) | BDBM50379862 (CHEMBL2011870) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at rat mGluR1 | Bioorg Med Chem Lett 22: 2514-7 (2012) Article DOI: 10.1016/j.bmcl.2012.02.003 BindingDB Entry DOI: 10.7270/Q2RX9D3G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50379862 (CHEMBL2011870) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Allosteric antagonist activity at human recombinant mGluR1 expressed in AV12 cells assessed as intracellular calcium concentration using Fluo-3 dye b... | Bioorg Med Chem Lett 22: 2514-7 (2012) Article DOI: 10.1016/j.bmcl.2012.02.003 BindingDB Entry DOI: 10.7270/Q2RX9D3G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50379862 (CHEMBL2011870) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at human mGluR5 | Bioorg Med Chem Lett 22: 2514-7 (2012) Article DOI: 10.1016/j.bmcl.2012.02.003 BindingDB Entry DOI: 10.7270/Q2RX9D3G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50379862 (CHEMBL2011870) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Allosteric antagonist activity at human recombinant mGluR1 expressed in AV12 cells assessed as intracellular calcium concentration using Fluo-3 dye b... | Bioorg Med Chem Lett 22: 2514-7 (2012) Article DOI: 10.1016/j.bmcl.2012.02.003 BindingDB Entry DOI: 10.7270/Q2RX9D3G | |||||||||||
More data for this Ligand-Target Pair |