BDBM50380625 CHEMBL2016872
SMILES: NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OCCCCOc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1
InChI Key: InChIKey=HFYJVMKRIIAVFV-SZAHLOSFSA-N
Data: 9 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasminogen (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of plasmin by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Medicines Company (Leipzig) GmbH US Patent | Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo... | US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of plasma kallikrein by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 34.2 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Medicines Company (Leipzig) GmbH US Patent | Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo... | US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 510 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Medicines Company (Leipzig) GmbH US Patent | Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo... | US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of thrombin by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 784 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of factor 10a by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Medicines Company (Leipzig) GmbH US Patent | Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo... | US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vitamin K-dependent protein C (Homo sapiens (Human)) | BDBM50380625 (CHEMBL2016872) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of activated protein C by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair |