BDBM50381155 CHEMBL2018216

SMILES: Clc1cccc(Cn2c(nn3c2nc(cc3=O)N2CCOCC2)C2CC2)c1Cl

InChI Key: InChIKey=KTMLCPCWNLTDRL-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50381155   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50381155 (CHEMBL2018216) Show SMILES Clc1cccc(Cn2c(nn3c2nc(cc3=O)N2CCOCC2)C2CC2)c1Cl Show InChI InChI=1S/C19H19Cl2N5O2/c20-14-3-1-2-13(17(14)21)11-25-18(12-4-5-12)23-26-16(27)10-15(22-19(25)26)24-6-8-28-9-7-24/h1-3,10,12H,4-9,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PI3Kgamma by continuous read time resolved fluorescence resonance energy transfer displacement assay				Bioorg Med Chem Lett 22: 3198-202 (2012) Article DOI: 10.1016/j.bmcl.2012.03.039 BindingDB Entry DOI: 10.7270/Q2TD9ZBP
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50381155 (CHEMBL2018216) Show SMILES Clc1cccc(Cn2c(nn3c2nc(cc3=O)N2CCOCC2)C2CC2)c1Cl Show InChI InChI=1S/C19H19Cl2N5O2/c20-14-3-1-2-13(17(14)21)11-25-18(12-4-5-12)23-26-16(27)10-15(22-19(25)26)24-6-8-28-9-7-24/h1-3,10,12H,4-9,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha by continuous read time resolved fluorescence resonance energy transfer displacement assay				Bioorg Med Chem Lett 22: 3198-202 (2012) Article DOI: 10.1016/j.bmcl.2012.03.039 BindingDB Entry DOI: 10.7270/Q2TD9ZBP
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50381155 (CHEMBL2018216) Show SMILES Clc1cccc(Cn2c(nn3c2nc(cc3=O)N2CCOCC2)C2CC2)c1Cl Show InChI InChI=1S/C19H19Cl2N5O2/c20-14-3-1-2-13(17(14)21)11-25-18(12-4-5-12)23-26-16(27)10-15(22-19(25)26)24-6-8-28-9-7-24/h1-3,10,12H,4-9,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PI3K beta-mediated AKT phosphorylation at serine 473 in PTEN deficient human MDA-MB-468 cells after 30 mins				Bioorg Med Chem Lett 22: 3198-202 (2012) Article DOI: 10.1016/j.bmcl.2012.03.039 BindingDB Entry DOI: 10.7270/Q2TD9ZBP
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50381155 (CHEMBL2018216) Show SMILES Clc1cccc(Cn2c(nn3c2nc(cc3=O)N2CCOCC2)C2CC2)c1Cl Show InChI InChI=1S/C19H19Cl2N5O2/c20-14-3-1-2-13(17(14)21)11-25-18(12-4-5-12)23-26-16(27)10-15(22-19(25)26)24-6-8-28-9-7-24/h1-3,10,12H,4-9,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta by continuous read time resolved fluorescence resonance energy transfer displacement assay				Bioorg Med Chem Lett 22: 3198-202 (2012) Article DOI: 10.1016/j.bmcl.2012.03.039 BindingDB Entry DOI: 10.7270/Q2TD9ZBP
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50381155 (CHEMBL2018216) Show SMILES Clc1cccc(Cn2c(nn3c2nc(cc3=O)N2CCOCC2)C2CC2)c1Cl Show InChI InChI=1S/C19H19Cl2N5O2/c20-14-3-1-2-13(17(14)21)11-25-18(12-4-5-12)23-26-16(27)10-15(22-19(25)26)24-6-8-28-9-7-24/h1-3,10,12H,4-9,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assay				Bioorg Med Chem Lett 22: 3198-202 (2012) Article DOI: 10.1016/j.bmcl.2012.03.039 BindingDB Entry DOI: 10.7270/Q2TD9ZBP
					More data for this Ligand-Target Pair