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SMILES: COc1cc(N)ccc1-c1nc2snc(-c3ccc(F)cc3F)c2c(=O)[nH]1

InChI Key: InChIKey=ROZAIVIPIKBUMP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50381316   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A


(Homo sapiens (Human))		BDBM50381316
PNG
(CHEMBL2019133)
Show SMILES COc1cc(N)ccc1-c1nc2snc(-c3ccc(F)cc3F)c2c(=O)[nH]1
Show InChI InChI=1S/C18H12F2N4O2S/c1-26-13-7-9(21)3-5-11(13)16-22-17(25)14-15(24-27-18(14)23-16)10-4-2-8(19)6-12(10)20/h2-7H,21H2,1H3,(H,22,23,25)
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Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Displacement of [3H]-cAMP from human recombinant PDE7A

Bioorg Med Chem Lett 22: 3223-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.025
BindingDB Entry DOI: 10.7270/Q2NP25F2
More data for this
Ligand-Target Pair